Search results for "C6 glioma cell"

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Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius

2009

Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.

EcdysoneStereochemistryHelleborusSaponinRanunculaceaePharmacognosyCell Linefurostanol saponinC6 glioma cellAnimalsSettore BIO/15 - Biologia FarmaceuticaMedicinal plantsCytotoxicitycytotoxic activityPharmacologychemistry.chemical_classificationMolecular StructureTraditional medicinebiologyPlant ExtractsGlycosideBiological activitySettore CHIM/06 - Chimica OrganicaSaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicRatsHelleborusSterolschemistryH. bocconei subsp. intermediuRanunculaceae

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